Marmaduke is trying to get attention from his neighbors by pretending to be lost, even though he's only one house away from where he lives. The woman is fooled, but the man sees right through him. Regardless, this is a classic cry for help, and likely masks some deep-seated issues that Marmaduke is trying to come to terms with (though this is just speculative, we may see a continuation of one or more past Marmaduke storylines... Don't be surprised if tomorrow's Marmaduke addresses things like the guilt Marmaduke feels about his father's suicide, or his ongoing struggle with cocaine addiction, or coming to terms with his bisexuality).