Marmaduke is instructed by his owner-lady to bark at their bitchy neighbor, who is coming over to air some (presumably dog-related) grievances.

Marmaduke is asked by his owner-lady if he missed her during her brief trip to the store, but she is about to discover that Marmaduke seized the opportunity of her absence to throw a dog party.

Marmaduke is trying to get attention from his neighbors by pretending to be lost, even though he's only one house away from where he lives. The woman is fooled, but the man sees right through him. Regardless, this is a classic cry for help, and likely masks some deep-seated issues that Marmaduke is trying to come to terms with (though this is just speculative, we may see a continuation of one or more past Marmaduke storylines... Don't be surprised if tomorrow's Marmaduke addresses things like the guilt Marmaduke feels about his father's suicide, or his ongoing struggle with cocaine addiction, or coming to terms with his bisexuality).

Marmaduke is mocking his owner-lady by wearing the same ridiculous hat she has on. Refusing to let herself be baited by Marmaduke's shit-eating grin, she asks her daughter to put another hat on him before they go on their walk and Marmaduke has the chance to humiliate the owner-lady in public.

Marmaduke has been identified as the ringleader of a gang of criminal dogs by a lady dressed as an acorn, who was apparently the target of some sort of wrongdoing perpetrated by said gang. The police officer's sideways glance towards the reader indicates that he is not taking her complaint very seriously, but the fact that he took the time to round up and arrange three dogs on a miniature police lineup contradicts this air of mild annoyance.

Marmaduke, ever fiscally responsible, has a brief panic attack at the local Gas Eat N'Go (sic) when he mistakes the price of a gallon of gas for how much hot dogs cost, but his owner quickly sets him straight.

Marmaduke has yet again monopolized the time, energy, and finances of his family during one of their periodic day-long shore excursions, and it begins to dawn on them that they are essentially unwitting slaves, operating under the illusion that they have free will even though they are constantly doing the bidding of a gigantic dog.

Marmaduke has somehow obtained a very large television, which has led him to construct an addition to his doghouse.

Marmaduke is up to something, and his neighbors are justifiably concerned.

Marmaduke has passed out in his owner's lap, prompting a houseguest to comment that having an enormous dog capable of fully immobilizing you just by napping on you must be a "pain in the neck." Marmaduke's owner agrees with this, but qualifies that he is a "sweet pain in the neck," indicating that she has made peace with her decision to care for a hulking canine monstrosity who has no concept of her needs or well-being.