Marmaduke has gained new corporate sponsorship.

Marmaduke is riding a skateboard. While this in and of itself is absolutely HYSTERICAL (dogs aren't supposed to be able to ride skateboards!), the gag is kicked into overdrive when it is revealed (via his owner-boy's exposition to his fellow tricycle enthusiast) that not only is Marmaduke a dog who can ride a skateboard, he is a dog that is phenomenally skilled at riding a skateboard. You could cut the comedic absurdity with a knife.

Marmaduke is licking his owner-boy, who tries to pass off dog saliva as hygenic.

Marmaduke hates doing drag, no matter how much creative control he is given.

Marmaduke is being guest-written by Ogden Nash.

Marmaduke is terrorizing a Parcel Delivery (TM) employee in jest.

Marmaduke has learned to move as fast as the characters in The Matrix. He is using this newfound ability to exasperate his owner-lady (who, for reasons still at large, is dressed like a Quaker today) while she cleans a window.

Marmaduke's owner-lady is guilting him into not killing her for trying to give him a bath.

Special "Choose Your Own Level of Anthropomorphization" Edition

Marmaduke is an aggressive and enthusiastic debator, regardless of what issue is being discussed, or which point of view he is arguing against, or the fact that he cannot speak a language.

OR

Marmaduke is barking at a couple of guys for being loud.

Marmaduke is staring down a fortune teller, daring her to say something negative about the future of dog food and incur his fearsome rage.